Biology / Bio 0899 · Atom · ~20 seconds

Tumor Suppressor Genes

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A tumor suppressor gene codes for a negative regulator; its mutation removes a block on division, contributing to cancer by loss of function.

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A functioning p53 gene halts division when DNA is damaged; a mutated p53 can no longer stop that cell dividing.

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A proto-oncogene causes cancer by gaining a harmful function; a tumor suppressor causes cancer by losing a protective one.