Biology / Bio 0524 · Atom · ~20 seconds
Competitive Inhibition
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A competitive inhibitor resembles an enzyme's substrate closely enough to bind its active site, blocking the true substrate from binding there instead.
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Malonate competitively inhibits succinate dehydrogenase by occupying the same active site succinate would normally bind.
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A competitive inhibitor's effect weakens as substrate concentration rises, since substrate and inhibitor are competing for the same site.