Biology / Bio 0875 · Atom · ~20 seconds
External Regulation of the Cell Cycle
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External regulation of the cell cycle triggers or blocks division through signals from outside the cell, including growth factors, nearby cell death, and physical crowding.
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A shortage of human growth hormone can inhibit division broadly enough to cause dwarfism, while an excess causes gigantism.
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A dividing cell always receives its initiating signal from outside — division is never a spontaneous, internal event.