Biology / Bio 0325 · Atom · ~20 seconds
Integral and Peripheral Proteins
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An integral protein spans or embeds within the phospholipid bilayer; a peripheral protein attaches to the membrane's surface without entering the bilayer.
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Some integral proteins cross the membrane once; others fold back and forth through it as many as a dozen times.
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Location — embedded versus surface-attached — distinguishes integral from peripheral, not function.