Biology / Bio 2921 · Atom · ~20 seconds
Lipid-Soluble versus Water-Soluble Receptor Location
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Lipid-soluble hormones bind receptors inside the target cell, in cytoplasm or nucleus; water-soluble hormones bind receptors on the outer cell surface, since they cannot cross the membrane.
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Prescribed prednisone, a synthetic steroid, crosses cell membranes like cortisol; injected insulin instead binds surface receptors.
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Thyroxine is an exception among amino acid-derived hormones, crossing the membrane via a transporter despite not being lipid-derived.