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Bacteria versus Archaea: Membrane Lipid Differences

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Bacterial membranes link fatty acids to glycerol by an ester bond; archaeal membranes link branched phytanyl chains to glycerol by an ether bond.

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Some archaeal membranes form a single lipid monolayer rather than the bilayer both bacteria and eukaryotes, otherwise share.

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This lipid difference, not shape or size, is one of the structural grounds for placing Bacteria and Archaea in separate domains.