Biology / Bio 1583 · Atom · ~20 seconds
Polygenic Disease Risk from Genome Analysis
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A polygenic disease's risk depends on multiple genes plus environment, so genome analysis yields an estimated risk pattern, not a determined outcome.
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A genome analysis for a polygenic condition can flag which contributing variants a genome carries, without any single variant determining outcome.
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Single-gene defects cause only a small fraction of common disease, so most risk screening cannot reduce to one gene.