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Biology  /  Bio 1329  ·  Atom · ~20 seconds

Eukaryotic Transcription Factors and Enhancers

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A eukaryotic gene's transcription rate is further tuned by factors binding enhancer sequences, which can lie far from the regulated gene.

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An activator bound to a distant enhancer can loop DNA to contact the promoter's initiation complex, boosting transcription.

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An enhancer's distance from its gene along the DNA does not limit its effect — DNA looping brings the two into contact regardless.