Biology / Bio 1315 · Atom · ~20 seconds
The trp Operon: Repressible, Negative Regulation
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The trp operon is repressible: when tryptophan is abundant, it binds a repressor protein that blocks the operon's operator, halting transcription.
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Two tryptophan molecules bind the trp repressor, changing its shape so it can bind the operator and block polymerase.
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The trp operon is switched off by tryptophan's presence, not on — abundant tryptophan signals the cell to stop making more.