Biology / Bio 1301 · Atom · ~20 seconds
Point Mutations: Nonsense
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A nonsense mutation changes a codon into a premature stop codon, ending translation early and producing a shortened, usually nonfunctional protein.
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A single base change converting a tyrosine codon into a stop codon halts the ribosome partway through the intended protein.
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A nonsense mutation is a single base change like missense, but its effect on the protein is far more disruptive.